Cancer of the microsatellite mutator phenotype.

Article

Cancer of the microsatellite mutator phenotype.

Biological chemistry - 1 Nov 1996

Perucho M

Abstract excerpt

This review focuses on the genomic instability underlying the microsatellite mutator phenotype (MMP) pathway for cancer. MMP was discovered by the application of DNA fingerprinting by Arbitrarily Primed PCR (AP-PCR) to the analysis of somatic genetic alterations in colon tumors. The unbiased natu...

Topics

Colorectal Neoplasms, Hereditary Nonpolyposis
DNA
DNA Fingerprinting
DNA Repair
Frameshift Mutation
Humans
Karyotyping
Microsatellite Repeats
Mutagenesis
Neoplasms
Phenotype
Polymerase Chain Reaction

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