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Article

Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.

Developmental biology - 10 Jul 1996

Boulet A M, Capecchi M R

Abstract excerpt

Mice carrying a nonfunctional allele of hoxc-4 have been generated by gene targeting. The phenotype of mice homozygous for this mutation is strikingly different from those reported in mice lacking the paralogous genes hoxa-4, hoxb-4, and hoxd-4. In contrast to the mutants of the paralogous family members, hoxc-4 homozygotes do not manifest abnormalities in the cervical vertebrae, but instead show vertebral...

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Identifiers

PMID: 8660891
DOI: 10.1006/dbio.1996.0159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.PMID 8660891Read ↗

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Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column.Semantic proximity Read ↗

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.Semantic proximity Read ↗

Functional specificity of Hoxa-4 in vertebral patterning lies outside of the homeodomain.Semantic proximity Read ↗

Gain of function mutations for paralogous Hox genes: implications for the evolution of Hox gene function.Semantic proximity Read ↗

Hox C cluster genes are dispensable for overall body plan of mouse embryonic development.Semantic proximity Read ↗

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