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Article

Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein.

Nature - 25 Jan 1996

Leatherwood J, Lopez-Girona A, Russell P

Abstract excerpt

In fission yeast, Cdc2 kinase has both positive and negative roles in regulating DNA replication, being first necessary for the transition from G1 to S phase and later required to prevent the re-initiation of DNA replication during G2. We report here that Cdc2 interacts with Orp2, a protein similar to the Orc2 replication factor subunit of Saccharomyces cerevisiae origin recognition complex (ORC). ORC binds...

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Identifiers

PMID: 8552194
DOI: 10.1038/379360a0

Genes

ORC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein.PMID 8552194Read ↗

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Functionally homologous DNA replication genes in fission and budding yeast.Semantic proximity Read ↗

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Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.Semantic proximity Read ↗

A WD-repeat protein stabilizes ORC binding to chromatin.Semantic proximity Read ↗

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