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Article

Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.

Molecular and cellular biology - 1 Sept 1991

Brizuela L, Chrebet G, Bostian K A, Parent S A

Abstract excerpt

FK-506 is a novel and potent antagonist of T-cell activation and an inhibitor of fungal growth. Its immunosuppressive activity can be antagonized by the structurally related antibiotic rapamycin, and both compounds interact with cytoplasmic FK-506-binding proteins (FKBPs) in T cells and yeast cells. In this paper, we show that FK-506 and two analogs inhibit vegetative growth of Saccharomyces cerevisiae in a...

Topics

Anti-Bacterial Agents
Antifungal Agents
Carrier Proteins
Drug Resistance, Microbial
Genes, Fungal
Immunosuppressive Agents
Mutation
Polyenes
Restriction Mapping
Saccharomyces cerevisiae
Sirolimus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tacrolimus

Tacrolimus Binding Proteins

Temperature

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Identifiers

PMID: 1715022
DOI: 10.1128/mcb.11.9.4616-4626.1991
PMCID: PMC361345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1715022-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.PMID 1715022Read ↗

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.Semantic proximity Read ↗

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.Semantic proximity Read ↗

The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.Semantic proximity Read ↗

Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs in Cryptococcus neoformansSemantic proximity Read ↗

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.Semantic proximity Read ↗

Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma.Semantic proximity Read ↗

Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.Semantic proximity Read ↗

The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.Semantic proximity Read ↗

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatusSemantic proximity Read ↗

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.Semantic proximity Read ↗

FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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