Article
Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.
The Journal of biological chemistry - 20 Oct 2006
Reinke Aaron, Chen Jenny C-Y, Aronova Sofia, Powers Ted
Abstract excerpt
The target of rapamycin (TOR) kinase is an important regulator of growth in eukaryotic cells. In budding yeast, Tor1p and Tor2p function as part of two distinct protein complexes, TORC1 and TORC2, where TORC1 is specifically inhibited by the antibiotic rapamycin. Significant insight into TORC1 function has been obtained using rapamycin as a specific small molecule inhibitor of TOR activity. Here we show that...
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