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Article

The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.

Gene - 30 Jul 1993

Koser P L, Eng W K, Bossard M J, McLaughlin M M, Cafferkey R, Sathe G M, Faucette L, Levy M A, Johnson R K, Bergsma D J, Livi G P

Abstract excerpt

Rapamycin (Rm) is a macrolide antifungal agent related to FK506 that exhibits potent immunosuppressive properties which are mediated through interaction with specific cytoplasmic receptors (FKBPs or RBPs, for FK506- and Rm-binding proteins, respectively). These proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity in vitro which is inhibited by the binding of Rm and FK506. In Saccharomyces...

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Source

Identifiers

PMID: 8325502
DOI: 10.1016/0378-1119(93)90264-4

Genes

RBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.PMID 8325502Read ↗

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Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.Semantic proximity Read ↗

Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.Semantic proximity Read ↗

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