Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PDGF-A is required for normal murine cardiovascular development.

Developmental biology - 25 May 1996

Schattemann G C, Loushin C, Li T, Hart C E

Abstract excerpt

Several lines of evidence suggest that platelet-derived growth factor A chain (PDGF-A) is required for normal embryonic cardiovascular development. To test this directly, we introduced anti-PDGF-A neutralizing antibodies into mouse deciduas in utero at Embryonic Days (E) 8.5, 9.5, and 10.5. This resulted in the selective disruption of PDGF-A ligand-receptor interactions in vivo for a period of 18-24 hr and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Blotting, Western
Share to Histocytochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Myocardium

Share to Phenotype

Share to Pregnancy

Source

Identifiers

PMID: 8654889
DOI: 10.1006/dbio.1996.9988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PDGF-A is required for normal murine cardiovascular development.PMID 8654889Read ↗

Insight into the physiological functions of PDGF through genetic studies in mice.Semantic proximity Read ↗

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.Semantic proximity Read ↗

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Semantic proximity Read ↗

The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions.Semantic proximity Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survivalSemantic proximity Read ↗

An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.Semantic proximity Read ↗

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.Semantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.Semantic proximity Read ↗

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.Semantic proximity Read ↗

PDGF-C and PDGF-D signaling in vascular diseases and animal models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.