Article
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.
Development (Cambridge, England) - 1 Sept 2000
Miquerol L, Langille B L, Nagy A
Abstract excerpt
Previous work has shown that heterozygocity for a null mutation of the VEGF-A gene, resulting in a 50% reduction in VEGF-A expression, is embryonic lethal at embroyonic day (E) 9.5 in mice. We now show that two- to threefold overexpression of VEGF-A from its endogenous locus results in severe abnormalities in heart development and embryonic lethality at E12.5-E14. The mutant embryos displayed an attenuated...
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