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Article

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

American journal of human genetics - 1 Jun 1996

Detera-Wadleigh S D, Badner J A, Goldin L R, Berrettini W H, Sanders A R, Rollins D Y, Turner G, Moses T, Haerian H, Muniec D, Nurnberger J I, Gershon E S

Abstract excerpt

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal...

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PMID: 8651306
PMCID: PMC1915054

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Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.PMID 8651306Read ↗

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