Article
Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.
American journal of human genetics - 1 Jun 1996
Detera-Wadleigh S D, Badner J A, Goldin L R, Berrettini W H, Sanders A R, Rollins D Y, Turner G, Moses T, Haerian H, Muniec D, Nurnberger J I, Gershon E S
Abstract excerpt
In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus...
Topics
- Bipolar Disorder
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Disease Susceptibility
- Female
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Lod Score
- Male
- Nuclear Family
- Pedigree
- Polymerase Chain Reaction