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Article

Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22.

Genomics - 1 Feb 1997

Smyth C, Kalsi G, Curtis D, Brynjolfsson J, O'Neill J, Rifkin L, Moloney E, Murphy P, Petursson H, Gurling H

Abstract excerpt

Following a report of a linkage study that yielded evidence for a susceptibility locus for bipolar affective disorder on the long arm of chromosome 21, we studied 23 multiply affected pedigrees collected from Iceland and the UK, using the markers PFKL, D21S171, and D21S49. Counting only bipolar cases as affected, a two-point LOD of 1.28 was obtained using D21S171 (theta = 0.01, alpha = 0.35), with three Icelandic...

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Source

Identifiers

PMID: 9119364
DOI: 10.1006/geno.1996.4486

Genes

PFKL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22.PMID 9119364Read ↗

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.Semantic proximity Read ↗

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Linkage analysis in bipolar pedigrees adds support for a susceptibility locus on 21q22.Semantic proximity Read ↗

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A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22.Semantic proximity Read ↗

A genetic linkage study of bipolar disorder and 13 markers on chromosome 11 including the D2 dopamine receptor.Semantic proximity Read ↗

A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.Semantic proximity Read ↗

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Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder.Semantic proximity Read ↗

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