Article
Linkage analysis in bipolar pedigrees adds support for a susceptibility locus on 21q22.
Psychiatric genetics - 1 Jun 2004
Kaneva Radka P, Chorbov Vesselin M, Milanova Vihra K, Kostov Christian S, Nickolov Kaloian I, Chakarova Christina F, Stoyanova Vesela S, Nikolova-Hill Amelia N, Krastev Stefan K, Onchev George N, Kremensky Ivo M, Kalaydjieva Luba V, Jablensky Assen V
Abstract excerpt
Several studies provide suggestive evidence of a susceptibility locus for bipolar disorder at chromosome 21q22-23. In an attempt to replicate these findings, we have analyzed linkage to 11 polymorphic markers from this region in 18 Bulgarian pedigrees with affective disorder. Two-point linkage analysis under assumption of homogeneity and a dominant model with reduced penetrance produced modest positive values for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.