Article
A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.
American journal of human genetics - 1 Jan 1999
Aita V M, Liu J, Knowles J A, Terwilliger J D, Baltazar R, Grunn A, Loth J E, Kanyas K, Lerer B, Endicott J, Wang Z, Penchaszadeh G, Gilliam T C, Baron M
Abstract excerpt
Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in tha...
Topics
- Bipolar Disorder
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Lod Score