Article
Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q.
American journal of medical genetics - 31 May 1997
Detera-Wadleigh S D, Badner J A, Yoshikawa T, Sanders A R, Goldin L R, Turner G, Rollins D Y, Moses T, Guroff J J, Kazuba D, Maxwell M E, Edenberg H J, Foroud T, Lahiri D, Nurnberger J I, Stine O C, McMahon F, Meyers D A, MacKinnon D, Simpson S, McInnis M, DePaulo J R, Rice J, Goate A, Gershon E S
Abstract excerpt
An initial genome scan was performed on 540 individuals from 97 families segregating bipolar disorder, collected through the National Institutes of Mental Health Genetics Initiative. We report here affected-sib-pair (ASP) data on 126 marker loci (approximately 68,000 genotypes) mapping to chromosomes 4, 7, 9, 18, 19, 20, and 21q, under three affection status models. Modest increases in identical-by-descent (IBD)...
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