Article
A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3.
Nature genetics - 1 Nov 1994
Straub R E, Lehner T, Luo Y, Loth J E, Shao W, Sharpe L, Alexander J R, Das K, Simon R, Fieve R R
Abstract excerpt
In a preliminary genome scan of 47 bipolar disorder families, we detected in one family a lod score of 3.41 at the PFKL locus on chromosome 21q22.3. The lod score is robust to marker allele frequencies, phenocopy rates and age-dependent penetrance, and remains strongly positive with changes in affection status. Fourteen other markers in 21q22.3 were tested on this family, with largely positive lod scores. Five of...
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