Article
A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3.
Nature genetics - 1 Nov 1994
Straub R E, Lehner T, Luo Y, Loth J E, Shao W, Sharpe L, Alexander J R, Das K, Simon R, Fieve R R
Abstract excerpt
In a preliminary genome scan of 47 bipolar disorder families, we detected in one family a lod score of 3.41 at the PFKL locus on chromosome 21q22.3. The lod score is robust to marker allele frequencies, phenocopy rates and age-dependent penetrance, and remains strongly positive with changes in affection status. Fourteen other markers in 21q22.3 were tested on this family, with largely positive lod scores. Five of...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Bipolar Disorder
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease