Article
Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.
Genes & development - 1 Oct 1992
Bargonetti J, Reynisdóttir I, Friedman P N, Prives C
Abstract excerpt
Wild-type p53 protein was shown to bind specifically to DNA sequences within SV40 (Bargonetti et al. 1991), the human ribosomal gene cluster (RGC) (Kern et al. 1991a), and the murine muscle creatine kinase gene (MCK) (Zambetti et al. 1992). However, a direct comparison of these three sites was no...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Base Sequence
- Blotting, Western
- Cells, Cultured
- Cloning, Molecular
- Creatine Kinase
- DNA
- DNA Fingerprinting
- Electrophoresis, Polyacrylamide Gel
- Humans
- Molecular Sequence Data
- Moths
- Mutation
- Oligonucleotides
- Substrate Specificity
- Tumor Suppressor Protein p53
- rRNA Operon