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Article

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

Genes & development - 1 Jul 1992

Zambetti G P, Bargonetti J, Walker K, Prives C, Levine A J

Abstract excerpt

It has been reported recently that the wild-type p53 gene product can positively regulate the expression of a test gene adjacent to the enhancer-promoter elements of the murine muscle-specific creatine kinase (MCK) gene. This discussion reports the identification of a wild-type p53 protein-specific DNA-binding element located within the p53-responsive region of the MCK enhancer-promoter element. This p53...

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Identifiers

PMID: 1628822
DOI: 10.1101/gad.6.7.1143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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