Article
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.
Genes & development - 1 Jul 1992
Zambetti G P, Bargonetti J, Walker K, Prives C, Levine A J
Abstract excerpt
It has been reported recently that the wild-type p53 gene product can positively regulate the expression of a test gene adjacent to the enhancer-promoter elements of the murine muscle-specific creatine kinase (MCK) gene. This discussion reports the identification of a wild-type p53 protein-specif...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Creatine Kinase
- DNA
- Gene Expression Regulation, Enzymologic
- Humans
- Molecular Sequence Data
- Muscles
- Mutation
- Promoter Regions, Genetic
- Regulatory Sequences, Nucleic Acid
- Temperature
- Transcriptional Activation
- Tumor Suppressor Protein p53