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Article

Mutant p53 proteins behave in a dominant, negative fashion in vivo.

Anticancer research - 1 Jan 2000

Hachiya M, Chumakov A, Miller C W, Akashi M, Said J, Koeffler H P

Abstract excerpt

The p53 encodes a cellular phosphoprotein that has been association with both neoplastic transformation and the control of cellular growth. Recent studies have reported that p53 also acts as a transcriptional regulator. We have studied transactivational properties of human wild-type and mutant p53 proteins representing 4 major mutational hotspots (codons 141, 175, 248, 273) as well as a double mutant...

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PMID: 7847818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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