Article
Mutant p53 proteins behave in a dominant, negative fashion in vivo.
Anticancer research - 1 Jan 2000
Hachiya M, Chumakov A, Miller C W, Akashi M, Said J, Koeffler H P
Abstract excerpt
The p53 encodes a cellular phosphoprotein that has been association with both neoplastic transformation and the control of cellular growth. Recent studies have reported that p53 also acts as a transcriptional regulator. We have studied transactivational properties of human wild-type and mutant p53 proteins representing 4 major mutational hotspots (codons 141, 175, 248, 273) as well as a double mutant...
Topics
- Base Sequence
- Binding Sites
- Codon
- Consensus Sequence
- Genes, Reporter
- Genes, p53
- Histidine
- Humans
- Molecular Sequence Data
- Mutation
- Transcription, Genetic
- Transcriptional Activation