Article
Cell-type- and promoter-dependent ts phenotype of p53 Val135.
Oncogene - 1 Dec 1993
Sehgal P B, Margulies L
Abstract excerpt
The p53 mutant Val135 is widely considered to have a wild-type (wt) phenotype at 32.5 degrees C, but not at 37 degrees C. The ability of wt murine p53 and its Val135 mutant to modulate transcription from the muscle-specific creatine kinase promoter (-3.3 kb pMCK), from a reporter construct containing two copies of the p53-binding DNA element from within MCK (p50-2), and from the interleukin-6 (IL-6) promoter...
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