Cell-type- and promoter-dependent ts phenotype of p53 Val135.

Article

Cell-type- and promoter-dependent ts phenotype of p53 Val135.

Oncogene - 1 Dec 1993

Sehgal P B, Margulies L

Abstract excerpt

The p53 mutant Val135 is widely considered to have a wild-type (wt) phenotype at 32.5 degrees C, but not at 37 degrees C. The ability of wt murine p53 and its Val135 mutant to modulate transcription from the muscle-specific creatine kinase promoter (-3.3 kb pMCK), from a reporter construct contai...

Topics

Animals
Chloramphenicol O-Acetyltransferase
Creatine Kinase
DNA
Genes, p53
HeLa Cells
Humans
Interleukin-6
Mice
Muscles
Mutation
Phenotype
Promoter Regions, Genetic
Temperature
Transcription, Genetic
Transfection
Up-Regulation
Valine

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