Identification of mutant adeno-associated virus Rep proteins which are dominant-negative for DNA helicase activity.

doi:10.1006/bbrc.1996.0399

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Article

Identification of mutant adeno-associated virus Rep proteins which are dominant-negative for DNA helicase activity.

Biochemical and biophysical research communications - 18 Mar 1996

Kyöstiö S R, Owens R A

Abstract excerpt

Adeno-associated virus type 2 (AAV) Rep proteins have been postulated to play a role in unwinding the 145-bp inverted terminal repeats during AAV DNA replication. Previous studies showed that AAV Rep78 and Rep68 could unwind a DNA partial duplex of 26 bp. In this work it is demonstrated that nucl...

Topics

Adenosine Triphosphate
Cell Nucleus
DNA Helicases
DNA-Binding Proteins
Dependovirus
Electrophoresis, Polyacrylamide Gel
HIV Long Terminal Repeat
Humans
Magnesium Chloride
Mutation
Plasmids
Recombinant Fusion Proteins
Repetitive Sequences, Nucleic Acid
Transfection
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 8645299
DOI: 10.1006/bbrc.1996.0399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8645299-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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