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Article

Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein

1 Apr 1995

Abstract excerpt

The DNA of human parvovirus adeno-associated virus type 2 (AAV) integrates preferentially into a defined region of human chromosome 19. Southern blots of genomic DNA from latently infected cell lines revealed that the provirus was not simply inserted into the cellular DNA. Both the proviral and adjoining cellular DNA organization indicated that integration occurred by a complex, coordinated process involving...

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Identifiers

PMID: 7884849
DOI: 10.1128/jvi.69.4.2038-2046.1995

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Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep proteinPMID 7884849Read ↗

A Rep recognition sequence is necessary but not sufficient for nicking of DNA by adeno-associated virus type-2 Rep proteins.Semantic proximity Read ↗

Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific RecombinationSemantic proximity Read ↗

Adeno-associated virus Type 2 Rep proteins mediate integration of lentiviral vectorsSemantic proximity Read ↗

Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA.Semantic proximity Read ↗

Identification of mutant adeno-associated virus Rep proteins which are dominant-negative for DNA helicase activity.Semantic proximity Read ↗

Exploiting the adenoassociated virus Rep protein to mediate site-specific integration into the human genome and optimisation of Ad/AAV vector designSemantic proximity Read ↗

A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19Semantic proximity Read ↗

Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitro.Semantic proximity Read ↗

The Rep Protein of Adeno-Associated Virus Type 2 Interacts with Single-Stranded DNA-Binding Proteins That Enhance Viral ReplicationSemantic proximity Read ↗

Mutation of a consensus purine nucleotide binding site in the adeno-associated virus rep gene generates a dominant negative phenotype for DNA replication.Semantic proximity Read ↗

Adeno-Associated Virus Rep78 Protein Interacts with Protein Kinase A and Its Homolog PRKX and Inhibits CREB-Dependent Transcriptional ActivationSemantic proximity Read ↗

Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.Semantic proximity Read ↗

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