Article
The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity.
Journal of virology - 1 Jun 1998
Smith R H, Kotin R M
Abstract excerpt
The rep gene of adeno-associated virus type 2 encodes four overlapping proteins from two separate promoters, termed P5 and P19. The P5-promoted Rep proteins, Rep78 and Rep68, are essential for viral DNA replication, and a wealth of data concerning the biochemical activities of these proteins has been reported. In contrast, data concerning the biochemical functions of the P19-promoted Rep proteins, Rep52 and...
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