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Article

Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination

1 May 2000

Abstract excerpt

Adeno-associated virus type 2 (AAV) is the only known eucaryotic virus capable of targeted integration in human cells. AAV integrates preferentially into human chromosome (ch) 19q13.3qter. The nonstructural proteins of AAV-2, Rep78 and Rep68, are essential for targeted integration. Rep78 and Rep68 are multifunctional proteins with diverse biochemical activities, including site-specific binding to AAV and ch-19...

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PMID: 10756007
DOI: 10.1128/jvi.74.9.3953-3966.2000

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Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific RecombinationPMID 10756007Read ↗

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