Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Biochemical Characterization of the Adeno-associated Virus Rep40 Helicase

29 Aug 2003

Abstract excerpt

The human adeno-associated virus (AAV) has generated much enthusiasm as a transfer vector for human gene therapy. Although clinical gene therapy trials have been initiated using AAV vectors, much remains to be learned regarding the basic mechanisms of virus replication, gene expression, and virion assembly. AAV encodes four nonstructural, or replication (Rep), proteins. The Rep78 and Rep68 proteins regulate viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12824181
DOI: 10.1074/jbc.m301537200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Biochemical Characterization of the Adeno-associated Virus Rep40 HelicasePMID 12824181Read ↗

Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.Semantic proximity Read ↗

The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity.Semantic proximity Read ↗

Residues within the B' motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2.Semantic proximity Read ↗

The Rep Protein of Adeno-Associated Virus Type 2 Interacts with Single-Stranded DNA-Binding Proteins That Enhance Viral ReplicationSemantic proximity Read ↗

Identification of mutant adeno-associated virus Rep proteins which are dominant-negative for DNA helicase activity.Semantic proximity Read ↗

Adeno-associated virus type 5 utilizes alternative translation initiation to encode a small Rep40-like protein.Semantic proximity Read ↗

Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production.Semantic proximity Read ↗

Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitro.Semantic proximity Read ↗

Characterization of adeno-associated virus rep protein inhibition of adenovirus E2a gene expression.Semantic proximity Read ↗

In vitro replication of adeno-associated virus DNASemantic proximity Read ↗

Adeno-associated virus type 2 Rep40 modulates the proliferation rate of Rep52-expressing HeLa cells.Semantic proximity Read ↗

Definition of Herpes Simplex Virus Type 1 Helper Activities for Adeno-Associated Virus Early Replication EventsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.