Analysis of adeno-associated virus (AAV) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV p5 and p19 mRNA levels.

doi:10.1128/JVI.68.5.2947-2957.1994

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Article

Analysis of adeno-associated virus (AAV) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV p5 and p19 mRNA levels.

Journal of virology - 1 May 1994

Kyöstiö S R, Owens R A, Weitzman M D, Antoni B A, Chejanovsky N, Carter B J

Abstract excerpt

The rep gene of adeno-associated virus type 2 (AAV) encodes four overlapping Rep proteins that are involved in gene regulation and replication of the virus. We studied here the regulation of mRNA transcribed from the AAV p5 and p19 promoters, using transient expression in human 293 cells followed...

Topics

Blotting, Northern
DNA-Binding Proteins
Dependovirus
Gene Expression Regulation, Viral
Genes, Viral
Humans
Mutation
Plasmids
Promoter Regions, Genetic
RNA, Messenger
RNA, Viral
Sequence Deletion
Structure-Activity Relationship
Transfection
Viral Proteins

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Identifiers

PMID: 8151765
DOI: 10.1128/JVI.68.5.2947-2957.1994
PMCID: PMC236783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8151765-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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