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Article

Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA.

21 Jun 1994

Abstract excerpt

AAV is unique among eukaryotic viruses in the ability of its DNA to integrate preferentially into a specific region of the human genome. Understanding AAV integration may aid in developing gene therapy systems with predictable integration sites. Using a gel mobility-shift assay, we have identified a DNA sequence within the AAV integration locus on human chromosome 19 which is specifically bound by the AAV Rep78...

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Identifiers

PMID: 8016070
DOI: 10.1073/pnas.91.13.5808

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Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA.PMID 8016070Read ↗

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A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19Semantic proximity Read ↗

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Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep proteinSemantic proximity Read ↗

Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human GenomeSemantic proximity Read ↗

Site-specific integration by adeno-associated virus.Semantic proximity Read ↗

Characterization of a preferred site on human chromosome 19q for integration of adeno‐associated virus DNA by non‐homologous recombination.Semantic proximity Read ↗

Identification of mutant adeno-associated virus Rep proteins which are dominant-negative for DNA helicase activity.Semantic proximity Read ↗

Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.Semantic proximity Read ↗

Targeted integration of adeno‐associated virus (AAV) into human chromosome 19.Semantic proximity Read ↗

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