Article
Novel and recurrent BRCA2 mutations in Italian breast/ovarian cancer families widen the ovarian cancer cluster region boundaries to exons 13 and 14.
Breast cancer research and treatment - 1 Dec 2014
Coppa Anna, Buffone Amelia, Capalbo Carlo, Nicolussi Arianna, D'Inzeo Sonia, Belardinilli Francesca, Colicchia Valeria, Petroni Marialaura, Granato Teresa, Midulla Cecilia, Zani Massimo, Ferraro Sergio, Screpanti Isabella, Gulino Alberto, Giannini Giuseppe
Abstract excerpt
Hereditary breast and ovarian cancer are mainly linked to mutations in BRCA1 and BRCA2 genes which confer a similar cumulative risk of developing breast cancer. Importantly, while BRCA2 mutation carriers generally have a lower cumulative risk for ovarian cancer, mutations clustered in the central portion of BRCA2 are associated with a higher proportion of ovarian compared with breast cancer cases. The boundaries...
Topics
- Adult
- Aged
- BRCA2 Protein
- Breast Neoplasms
- Breast Neoplasms, Male
- Exons
- Female
- Germ-Line Mutation
- Humans
- Italy
- Male
- Middle Aged
- Mutation