Article
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.
Nature genetics - 1 Jul 2007
Stacey Simon N, Manolescu Andrei, Sulem Patrick, Rafnar Thorunn, Gudmundsson Julius, Gudjonsson Sigurjon A, Masson Gisli, Jakobsdottir Margret, Thorlacius Steinunn, Helgason Agnar, Aben Katja K, Strobbe Luc J, Albers-Akkers Marjo T, Swinkels Dorine W, Henderson Brian E, Kolonel Laurence N, Le Marchand Loic, Millastre Esther, Andres Raquel, Godino Javier, Garcia-Prats Maria Dolores, Polo Eduardo, Tres Alejandro, Mouy Magali, Saemundsdottir Jona, Backman Valgerdur M, Gudmundsson Larus, Kristjansson Kristleifur, Bergthorsson Jon T, Kostic Jelena, Frigge Michael L, Geller Frank, Gudbjartsson Daniel, Sigurdsson Helgi, Jonsdottir Thora, Hrafnkelsson Jon, Johannsson Jakob, Sveinsson Thorarinn, Myrdal Gardar, Grimsson Hlynur Niels, Jonsson Thorvaldur, von Holst Susanna, Werelius Barbro, Margolin Sara, Lindblom Annika, Mayordomo Jose I, Haiman Christopher A, Kiemeney Lambertus A, Johannsson Oskar Th, Gulcher Jeffrey R, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari
Abstract excerpt
Familial clustering studies indicate that breast cancer risk has a substantial genetic component. To identify new breast cancer risk variants, we genotyped approximately 300,000 SNPs in 1,600 Icelandic individuals with breast cancer and 11,563 controls using the Illumina Hap300 platform. We then tested selected SNPs in five replication sample sets. Overall, we studied 4,554 affected individuals and 17,577...
Topics
- Breast Neoplasms
- Case-Control Studies
- Chromosomes, Human, Pair 16