Article
Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development?
Journal of virology - 1 Apr 1996
Baxter E W, Blyth K, Donehower L A, Cameron E R, Onions D E, Neil J C
Abstract excerpt
The effect of Moloney murine leukemia virus (MoMLV) infection was examined in mice lacking a functional p53 gene. Virus-infected p53-/- mice developed tumors significantly faster than uninfected p53-/- or virus-infected p53+/+ littermates. However, the degree of synergy between MoMLV and the p53...
Topics
- Alleles
- Animals
- Base Sequence
- DNA Primers
- Gene Frequency
- Gene Rearrangement
- Genes, myc
- Genetic Heterogeneity
- Genotype
- Lymphoma
- Mice
- Mice, Transgenic
- Mink Cell Focus-Inducing Viruses
- Molecular Sequence Data
- Moloney murine leukemia virus
- Mutagenesis, Insertional
- Phenotype
- Protein Serine-Threonine Kinases