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Article

Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development?

Journal of virology - 1 Apr 1996

Baxter E W, Blyth K, Donehower L A, Cameron E R, Onions D E, Neil J C

Abstract excerpt

The effect of Moloney murine leukemia virus (MoMLV) infection was examined in mice lacking a functional p53 gene. Virus-infected p53-/- mice developed tumors significantly faster than uninfected p53-/- or virus-infected p53+/+ littermates. However, the degree of synergy between MoMLV and the p53 null genotype was weaker than the synergy between either of these and c-myc transgenes. A similar range of T-cell tumor...

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Identifiers

PMID: 8642629
DOI: 10.1128/JVI.70.4.2095-2100.1996
PMCID: PMC190045

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Source receipt: pubmed, retrieved 7 Sept 2026.

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