Article
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.
Oncogene - 6 Jul 1995
Elson A, Deng C, Campos-Torres J, Donehower L A, Leder P
Abstract excerpt
A number of properties of the cancer-related genes c-myc and p53 suggest that they might collaborate to induce tumorigenesis. To test this notion, we produced doubly heterozygotic mice bearing disrupted p53 alleles and a fusion transgene consisting of the mouse mammary tumor virus (MMTV) LTR and the oncogene c-myc. Mice bearing both the MMT/c-myc transgene and a single p53- allele develop very aggressive pre-T-...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.