Article
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.
Oncogene - 6 Jul 1995
Elson A, Deng C, Campos-Torres J, Donehower L A, Leder P
Abstract excerpt
A number of properties of the cancer-related genes c-myc and p53 suggest that they might collaborate to induce tumorigenesis. To test this notion, we produced doubly heterozygotic mice bearing disrupted p53 alleles and a fusion transgene consisting of the mouse mammary tumor virus (MMTV) LTR and...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- Female
- Gene Expression Regulation, Developmental
- Genes, myc
- Genes, p53
- Genotype
- Heterozygote
- Lymphoma, T-Cell
- Male
- Mammary Glands, Animal
- Mammary Neoplasms, Experimental
- Mammary Tumor Virus, Mouse