Article
Dissecting p53 tumor suppressor functions in vivo.
Cancer cell - 1 Apr 2002
Schmitt Clemens A, Fridman Jordan S, Yang Meng, Baranov Eugene, Hoffman Robert M, Lowe Scott W
Abstract excerpt
Although the p53 tumor suppressor acts in a plethora of processes that influence cellular proliferation and survival, it remains unclear which p53 functions are essential for tumor suppression and, as a consequence, are selected against during tumor development. Using a mouse model harboring primary, genetically modified myc-driven lymphomas, we show that disruption of apoptosis downstream of p53 by Bcl2 or a...
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