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Article

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.

Diabetologia - 1 Jun 2007

Florez J C, Sjögren M, Agapakis C M, Burtt N P, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly M J, Ardlie K G, Hirschhorn J N, Altshuler D, Groop L

Abstract excerpt

AIMS/HYPOTHESIS: Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the insulin signalling pathway. Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabetes, we and others have not observed this association in well-powered samples. However, other nearby variants might account for the putative association signal. SUBJECTS AND METHODS: We...

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Identifiers

PMID: 17443311
DOI: 10.1007/s00125-007-0657-5

Genes

IRS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.PMID 17443311Read ↗

The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.Semantic proximity Read ↗

Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.Semantic proximity Read ↗

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.Semantic proximity Read ↗

IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.Semantic proximity Read ↗

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.Semantic proximity Read ↗

A functional variant of IRS1 is associated with type 1 diabetes in families from the US and UK.Semantic proximity Read ↗

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.Semantic proximity Read ↗

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.Semantic proximity Read ↗

Lack of association between the insulin receptor substrates-1 Gly972Arg polymorphism and type-2 diabetes mellitus among Saudis from Eastern Saudi Arabia.Semantic proximity Read ↗

Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population.Semantic proximity Read ↗

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