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Article

Relationship between insulin sensitivity and insulin receptor substrate-1 mutations in non-diabetic relatives of NIDDM families.

Diabetic medicine : a journal of the British Diabetic Association - 1 Apr 1996

Armstrong M, Haldane F, Avery P J, Mitcheson J, Stewart M W, Turnbull D M, Walker M

Abstract excerpt

Insulin receptor substrate-1 (IRS-1) occupies a key position in the insulin-signalling pathway. Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) rema...

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Source

Identifiers

PMID: 9162610
DOI: 10.1002/(SICI)1096-9136(199604)13:4<341::AID-DIA80>3.0.CO;2-F

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9162610-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Relationship between insulin sensitivity and insulin receptor substrate-1 mutations in non-diabetic relatives of NIDDM families.PMID 9162610Read ↗

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.Semantic proximity Read ↗

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.Semantic proximity Read ↗

IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistanceSemantic proximity Read ↗

UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study.Semantic proximity Read ↗

Insulin sensitivity is not affected by mutation of codon 972 of the human IRS-1 gene.Semantic proximity Read ↗

Human insulin receptor substrate-1: variant sequences in familial non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes.Semantic proximity Read ↗

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDMSemantic proximity Read ↗

The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.Semantic proximity Read ↗

The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.Semantic proximity Read ↗

No association between the Gly971Arg variant of the insulin receptor substrate 1 gene and NIDDM in the Taiwanese population.Semantic proximity Read ↗

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