Article
Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Dec 1997
Imai Y, Philippe N, Sesti G, Accili D, Taylor S I
Abstract excerpt
Several polymorphisms have been identified in the amino acid sequence of human insulin receptor substrate-1 (IRS-1). Some of the variant sequences have been reported to be increased in prevalence among patients with noninsulin-dependent diabetes mellitus (NIDDM). This observation led to the hypot...
Topics
- Adaptor Proteins, Signal Transducing
- Cell Line
- Diabetes Mellitus, Type 2
- GRB2 Adaptor Protein
- Genetic Variation
- Humans
- Insulin
- Insulin Receptor Substrate Proteins
- Mutation
- Peptide Fragments
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Phosphorylation
- Proteins
- Tyrosine