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Article

Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus.

The Journal of clinical endocrinology and metabolism - 1 Dec 1997

Imai Y, Philippe N, Sesti G, Accili D, Taylor S I

Abstract excerpt

Several polymorphisms have been identified in the amino acid sequence of human insulin receptor substrate-1 (IRS-1). Some of the variant sequences have been reported to be increased in prevalence among patients with noninsulin-dependent diabetes mellitus (NIDDM). This observation led to the hypothesis that these amino acid substitutions may impair the function of IRS-1, thereby causing the insulin resistance seen...

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Source

Identifiers

PMID: 9398740
DOI: 10.1210/jcem.82.12.4429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus.PMID 9398740Read ↗

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Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus. Mutations in brief no. 130. Online.Semantic proximity Read ↗

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.Semantic proximity Read ↗

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