Article
Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds.
American journal of human genetics - 1 Jan 2001
Scott R J, McPhillips M, Meldrum C J, Fitzgerald P E, Adams K, Spigelman A D, du Sart D, Tucker K, Kirk J
Abstract excerpt
Hereditary nonpolyposis colorectal cancer (HNPCC) describes the condition of a disparate group of families that have in common a predisposition to colorectal cancer in the absence of a premalignant phenotype. The genetic basis of this disease has been linked to mutations in genes associated with DNA mismatch repair. A large proportion of families harbor changes in one of two genes, hMSH2 and hMLH1. Approximately...
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