Article
Allelic imbalance on chromosome 3p in oral dysplastic lesions: an early event in oral carcinogenesis.
Cancer research - 15 Mar 1996
Roz L, Wu C L, Porter S, Scully C, Speight P, Read A, Sloan P, Thakker N
Abstract excerpt
We have demonstrated previously a loss of constitutional heterozygosity on the short arm of chromosome 3 in approximately 50% of oral squamous cell carcinomas. In the present study, we have investigated 30 oral dysplastic lesions (DLs), presenting clinically as either erythroplakias or leukoplakias with histopathological features of either severe epithelial dysplasia or carcinoma in situ, for LOH on chromosome 3p...
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