Article
Frequent gene deletions in potentially malignant oral lesions.
British journal of cancer - 1 Mar 1996
Emilion G, Langdon J D, Speight P, Partridge M
Abstract excerpt
Some oral cancers are preceded by premalignant lesions which include leucoplakia and erythroplakia. At present there are no reliable markers to identify lesions that may progress to malignancy. We have analysed 30 potentially malignant oral lesions for deletions at chromosomal regions that harbour tumour-suppressor genes for oral cancer. A total of 16 of 30 cases (53%) showed loss of heterozygosity (LOH) or...
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