The genetic basis of oral leukoplakia and its key role in understanding oral carcinogenesis.

doi:10.1111/jop.13140

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Article

The genetic basis of oral leukoplakia and its key role in understanding oral carcinogenesis.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Aug 2021

Guimarães Letícia Martins, Diniz Marina Gonçalves, Rogatto Sílvia Regina, Gomez Ricardo Santiago, Gomes Carolina Cavalieri

Abstract excerpt

Oral leukoplakia (OL) is the most common oral potentially malignant disorder, with a global prevalence of 2%-3%, variable malignant transformation rate and incompletely understood aetiology. Considering the subjectivity in oral dysplasia grading, other evaluation methods have been tested as predictors of malignant transformation. DNA ploidy status and loss of heterozygosity signatures have been shown to be good...

Topics

Cell Transformation, Neoplastic
Humans
Hyperplasia
Leukoplakia, Oral
Mutation
Ploidies

Source

Open in PubMed

Identifiers

PMID: 33217066
DOI: 10.1111/jop.13140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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