Article
Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo.
Genetics - 1 Mar 2012
Kunttas-Tatli Ezgi, Zhou Meng-Ning, Zimmerman Sandra, Molinar Olivia, Zhouzheng Fangyuan, Carter Krista, Kapur Megha, Cheatle Alys, Decal Richard, McCartney Brooke M
Abstract excerpt
The tumor suppressor Adenomatous polyposis coli (APC) negatively regulates Wnt signaling through its activity in the destruction complex. APC binds directly to the main effector of the pathway, β-catenin (βcat, Drosophila Armadillo), and helps to target it for degradation. In vitro studies demonstrated that a nonphosphorylated 20-amino-acid repeat (20R) of APC binds to βcat through the N-terminal extended region...
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