Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model.

Oncogene - 10 Apr 2008

Rao P R, Makhijani K, Shashidhara L S

Abstract excerpt

There have been conflicting reports on the requirement of GSK-3beta-mediated phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) vis-à-vis its ability to bind and degrade beta-catenin. Using a unique combination of loss of function for Shaggy/GSK-3beta and a gain of function for human APC in Drosophila, we show that misexpressed human APC (hAPC) can still sequester Armadillo/beta-catenin. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to beta Catenin
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Models, Animal

Share to Protein Binding

Source

Identifiers

PMID: 17968317
DOI: 10.1038/sj.onc.1210890

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model.PMID 17968317Read ↗

A new Drosophila APC homologue associated with adhesive zones of epithelial cells.Semantic proximity Read ↗

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.Semantic proximity Read ↗

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Semantic proximity Read ↗

A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels.Semantic proximity Read ↗

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo.Semantic proximity Read ↗

Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.Semantic proximity Read ↗

Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.Semantic proximity Read ↗

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.Semantic proximity Read ↗

Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.Semantic proximity Read ↗

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.