Article
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.
The EMBO journal - 3 Feb 2003
Dajani Rana, Fraser Elizabeth, Roe S Mark, Yeo Maggie, Good Valerie M, Thompson Vivienne, Dale Trevor C, Pearl Laurence H
Abstract excerpt
Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine kinase involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3beta is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates beta-catenin, marking it for ubiquitylation and destruction. We have now determined the crystal structure of GSK3beta in complex with a minimal GSK3beta-binding...
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