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Article

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

Science (New York, N.Y.) - 24 Apr 1998

Behrens J, Jerchow B A, Würtele M, Grimm J, Asbrand C, Wirtz R, Kühl M, Wedlich D, Birchmeier W

Abstract excerpt

Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of condu...

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PMID: 9554852
DOI: 10.1126/science.280.5363.596

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9554852-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.PMID 9554852Read ↗

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.Semantic proximity Read ↗

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin levelSemantic proximity Read ↗

Aberrant Wnt/β-catenin signaling can induce chromosomal instability in colon cancerSemantic proximity Read ↗

Wnt/beta-catenin signaling.Semantic proximity Read ↗

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Semantic proximity Read ↗

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.Semantic proximity Read ↗

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.Semantic proximity Read ↗

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βSemantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Mouse axin and axin2/conductin proteins are functionally equivalent in vivo.Semantic proximity Read ↗

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.Semantic proximity Read ↗

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled.Semantic proximity Read ↗

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