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Article

Intergeneric poliovirus recombinants for the treatment of malignant glioma

6 Jun 2000

Abstract excerpt

Poliovirus neuropathogenicity depends on sequences within the 5' nontranslated region of the virus. Exchange of the poliovirus internal ribosomal entry site with its counterpart from human rhinovirus type 2 resulted in attenuation of neurovirulence in primates. Despite deficient virus propagation in cells of neuronal origin, nonpathogenic polio recombinants retain excellent growth characteristics in cell lines...

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Identifiers

PMID: 10841575
DOI: 10.1073/pnas.97.12.6803

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