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Article

Genetic Determinants of Cell Type-Specific Poliovirus Propagation in HEK 293 Cells

27 Apr 2005

Abstract excerpt

The ability of poliovirus to propagate in neuronal cells can be reduced by introducing appropriate nucleotide substitutions into the viral genome. Specific mutations scattered throughout the poliovirus genome yielded the live attenuated vaccine strains of poliovirus. Neuron-specific propagation deficits of the Sabin strains are partially encrypted within a confined region of the internal ribosomal entry site...

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PMID: 15858012
DOI: 10.1128/jvi.79.10.6281-6290.2005

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