Article
Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells.
Oncogene - 1 Feb 1996
Menke A L, Riteco N, van Ham R C, de Bruyne C, Rauscher F J, van der Eb A J, Jochemsen A G
Abstract excerpt
The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Blotting, Western
- Cell Line
- Cell Transformation, Neoplastic
- Consensus Sequence
- DNA, Complementary
- DNA-Binding Proteins
- Genes, Wilms Tumor
- Genetic Variation
- Humans
- Kidney
- Kidney Neoplasms
- Mice
- Mice, Nude
- Molecular Sequence Data
- Oligodeoxyribonucleotides