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Article

A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription.

PloS one - 1 Jan 2015

Bagchi Debalina, Andrade Josefa, Shupnik Margaret A

Abstract excerpt

Luteinizing hormone (LH) is synthesized and secreted throughout the reproductive cycle from gonadotrope cells in the anterior pituitary, and is required for steroidogenesis and ovulation. LH contains an α-subunit common with FSH, and a unique LHβ subunit that defines biological activity. Basal LHβ transcription is low and stimulated by hypothalamic GnRH, which induces synthesis of early growth response protein-1...

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Identifiers

PMID: 25617744
DOI: 10.1371/journal.pone.0116825
PMCID: PMC4305298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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