Article
Mice lacking the 68-amino-acid, mammal-specific N-terminal extension of WT1 develop normally and are fertile.
Molecular and cellular biology - 1 Apr 2003
Miles Colin G, Slight Joan, Spraggon Lee, O'Sullivan Maureen, Patek Charles, Hastie Nicholas D
Abstract excerpt
Mutations in the Wilms' tumor 1 gene, WT1, cause pediatric nephroblastoma and the severe genitourinary disorders of Frasier and Denys-Drash syndromes. High levels of WT1 expression are found in the developing kidney, uterus, and testis--consistent with this finding, the WT1 knockout mouse demonstrates that WT1 is essential for normal genitourinary development. The WT1 gene encodes multiple isoforms of a zinc...
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