RNA editing in the Wilms' tumor susceptibility gene, WT1.

doi:10.1101/gad.8.6.720

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Article

RNA editing in the Wilms' tumor susceptibility gene, WT1.

Genes & development - 15 Mar 1994

Sharma P M, Bowman M, Madden S L, Rauscher F J, Sukumar S

Abstract excerpt

Rat kidney WT1 cDNAs contain either a thymidine or a cytosine residue at position 839. Genomic WT1 DNA contains only T839. To explain these results, we propose the WT1 transcript undergoes RNA editing in which U839 is converted to C, resulting in the replacement of leucine 280 in WT1 by proline....

Topics

Animals
Base Sequence
DNA-Binding Proteins
Exons
Genes, Wilms Tumor
Genetic Predisposition to Disease
Humans
Introns
Kidney
Kidney Neoplasms
Molecular Sequence Data
Oligodeoxyribonucleotides
Polymerase Chain Reaction
RNA, Messenger
Rats
Restriction Mapping
Transcription, Genetic
WT1 Proteins

Source

Open in PubMed

Identifiers

PMID: 7926762
DOI: 10.1101/gad.8.6.720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7926762-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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