Article
RNA editing in the Wilms' tumor susceptibility gene, WT1.
Genes & development - 15 Mar 1994
Sharma P M, Bowman M, Madden S L, Rauscher F J, Sukumar S
Abstract excerpt
Rat kidney WT1 cDNAs contain either a thymidine or a cytosine residue at position 839. Genomic WT1 DNA contains only T839. To explain these results, we propose the WT1 transcript undergoes RNA editing in which U839 is converted to C, resulting in the replacement of leucine 280 in WT1 by proline. RNA editing at the same nucleotide was observed in WT1 cDNAs from human testis. In functional assays, the...
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