Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional properties of WT1.

Medical and pediatric oncology - 1 Nov 1996

Haber D A, Englert C, Maheswaran S

Abstract excerpt

WT1 encodes a zinc finger transcription factor that is inactivated in a subset of Wilms' tumors. We have recently shown that introduction of wild-type WT1 into a Wilms' tumor-derived cell line, RM1, results in growth suppression, consistent with its function as a tumor suppressor gene. WT1-mediated growth suppression was also observed in other cells derived from embryonal tumors, including two osteosarcoma cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Gene Expression Regulation, Neoplastic
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Transcription Factors

Share to Transcription, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8827073
DOI: 10.1002/(SICI)1096-911X(199611)27:5<453::AID-MPO11>3.0.CO;2-B

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional properties of WT1.PMID 8827073Read ↗

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene.Semantic proximity Read ↗

Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapySemantic proximity Read ↗

The complex life of WT1.Semantic proximity Read ↗

Induction of p21 by the Wilms' tumor suppressor gene WT1.Semantic proximity Read ↗

Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation.Semantic proximity Read ↗

The role of the Wilms tumour gene (<i>WT1</i>) in normal and malignant haematopoiesisSemantic proximity Read ↗

Wilms' Tumor Suppressor Gene WT1Semantic proximity Read ↗

Analysis of WT1 target gene expression in stably transfected cell lines.Semantic proximity Read ↗

Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 MutationsSemantic proximity Read ↗

The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanismSemantic proximity Read ↗

Role of the Wilms’ tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanismsSemantic proximity Read ↗

Wilms’ Tumor GeneWT1: Its Oncogenic Function and Clinical ApplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.