Article
A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992
Haber D A, Timmers H T, Pelletier J, Sharp P A, Housman D E
Abstract excerpt
Wilms tumor is a pediatric kidney cancer that has been linked to the inactivation of a tumor-suppressor gene at chromosome locus 11p13. The WT1 gene, mapping to this locus, is developmentally regulated in the kidney and encodes a putative transcription factor that has been shown to be mutated in Wilms tumor specimens. We have suggested that one such altered product of the WT1 gene may be capable of trans-dominant...
Topics
- Adenovirus Early Proteins
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA-Binding Proteins
- Gene Expression
- Genes, Dominant
- Genes, Tumor Suppressor
- In Vitro Techniques
- Macromolecular Substances