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Article

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

The Journal of biological chemistry - 2 May 2014

Mustaev Arkady, Malik Muhammad, Zhao Xilin, Kurepina Natalia, Luan Gan, Oppegard Lisa M, Hiasa Hiroshi, Marks Kevin R, Kerns Robert J, Berger James M, Drlica Karl

Abstract excerpt

DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA, passing duplex DNA through the break, and then resealing the break. This process is subject to reversible corruption by fluoroquinolones, antibacterials that form drug-enzyme-DNA complexes in which the DNA is broken. The complexes, called cleaved complexes because of the presence of DNA breaks, have been crystallized and found to have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24497635
DOI: 10.1074/jbc.M113.529164
PMCID: PMC4007428

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